Skip to main content

Table 1 Characteristics of confirmed vs. unconfirmed ILD cases following clinical adjudication

From: Validation of an algorithm to identify incident interstitial lung disease in patients with rheumatoid arthritis

 

Yes, confirmed ILD

No, not confirmed ILD

Insufficient information to determine

P value

SMD (comparing all three groups)

N

108

126

39

  

Age (mean (sd))

66 (9.7)

67 (9.6)

67 (10.2)

0.80

0.06

Male sex (%)

36 (33.3)

32 (25.4)

7 (17.9)

0.14

0.24

Race (%)

   

0.52

0.34

 White

78 (72.9)

92 (73.6)

32 (82.1)

-

-

 Black

22 (20.6)

21 (16.8)

7 (17.9)

-

-

 Unknown

5 (4.7)

10 (8.0)

0 (0.0)

-

-

 Other

2 (1.9)

2 (1.6)

0 (0.0)

-

-

Weighted Charlson indexa (mean (sd))

2 (1.5)

2 (1.5)

2 (1.9)

0.95

0.03

Comorbidities

 Cerebrovascular disease (%)

8 (7.4)

11 (8.7)

2 (5.1)

0.75

0.10

 Congestive heart failure (%)

15 (13.9)

21 (16.7)

7 (17.9)

0.78

0.07

 Diabetes without complications (%)

26 (24.1)

18 (14.3)

11 (28.2)

0.07

0.23

 Diabetes with complications (%)

8 (7.4)

6 (4.8)

2 (5.1)

0.68

0.07

 Myocardial infarction (%)

9 (8.3)

6 (4.8)

2 (5.1)

0.51

0.10

 Peripheral vascular disease (%)

11 (10.2)

14 (11.1)

3 (7.7)

0.83

0.08

 Renal disease (%)

9 (8.3)

14 (11.1)

5 (12.8)

0.67

0.10

Any tobacco use (%)

21 (19.4)

30 (23.8)

11 (28.2)

0.49

0.14

RA Medications, any prior use (%)

 Methotrexate (%)

39 (36.1)

56 (44.4)

20 (51.3)

0.20

0.21

 Biologic DMARDS (%)

43 (39.8)

49 (38.9)

10 (25.6)

0.26

0.20

 Glucocorticoids, e.g., prednisone (%)

69 (63.9)

70 (55.6)

23 (59.0)

0.43

0.11

  1. Note: All variables in the Charlson and each of the specific comorbidities were ascertained using the 12 months prior to the index date. All other variables including tobacco use and RA medications were classified based on all prior historical data available
  2. ILD interstitial lung disease, SMD standardized mean difference
  3. aExcluding RA in the Charlson weighting