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Table 1 Tissue engineering-based applications of IGF-1

From: Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Growth factors Scaffolds Cells Effect References
IGF-1/BMP-2 Fibrin glue Mesenchymal cells isolated from rib perichondrium Infecting mesenchymal stem cells with the adenoviral vectors AdBMP-2 and AdIGF-1 to induce transparent cartilage repair [16]
IGF-1/TGF-β Polyglycolic acid (PGA) scaffolds Chondrocytes The presence of IGF-1/TGF-β,or genetically modified chondrocytes overexpressing IGF-1 significantly improved osteochondral repair [46, 48]
IGF-1 Type II collagen glycosaminoglycan (CG) scaffold Adult articular chondrocytes Continuous local overexpression of IGF-1 leads to enhanced cartilage formation [49]
IGF-1/BMP-2 Bilayered oligo (poly(ethylene glycol) fumarate) (OPF) hydrogel composites Mesenchymal stem cells IGF-1 and BMP-2 can synergistically enhance the formation of subchondral bone, and the delivery of IGF-1 alone has a positive effect on the repair of osteochondral tissue [50, 51]