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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis

Fig. 1

WNT16 is highly expressed in facet joint of AS. A Heatmap diagram of differentially expressed probes mapped to Wnt genes in AS and control osteoprogenitor cells. In AS osteoprogenitor cells, WNT16 showed significant upregulated expression with a p value < 0.05 and fold change > 2 compared to the control (n=3 per each group). B Verification of mRNA level using qPCR of A for the Wnt family (n=6 per each group). C Immunoblotting for WNT16 protein level in control and AS-osteoprogenitor cells (n=5 per each group). D Immunohistochemistry (IHC) staining of WNT16 in spinal facet joint tissue from control or AS patients. Black arrows indicate bone-lining cells, and blue arrows indicate periosteum in facet joints tissues. Three representative images are shown (n=7 per each group). Data are presented as the median and interquartile range. *p<0.05, **p<0.01

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