Fig. 3

Cenerimod treatment reduces local inflammation and improves salivary gland function in the viral sialadenitis model. A Heatmap plots from 26 cytokine/chemokines using Luminex technology with red representing high protein concentrations and blue low protein concentrations. Each vertical line represents protein values from one individual mouse taken at the end of early therapeutic treatment (day 15). B Overall inflammatory score represented as box and whiskers plot. Data points represent, for each cytokine, the median within each group after scaling and centering the values. A line is drawn between two points to join the values of each cytokine in both groups. C,D Quantification of protein concentrations of T cell and myeloid cell attracting chemokines (C) and inflammatory cytokines (D) from the salivary gland using Luminex technology at the end of treatment (day 15). E Saliva production as measured by microlitres of saliva produced in 10 min per gram body weight at the end of treatment (day 15). Cenerimod groups are shown as a percentage of vehicle. C–E Each data point represents the measurement of individual mice from three independent experiments with 3–4 mice per group; horizontal line indicates the median, the box indicates the upper and lower quartiles and the whiskers indicate the minimum and maximum range; *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle group (Mann-Whitney test); Tx, therapeutic; SG, salivary gland