Fig. 4

Cenerimod treatment reduces blood and salivary gland infiltrates in the MRL/lpr mouse model. A Study design in MRL/lpr female mice; mice (n = 20 per group) were 7 weeks of age at treatment start (week 1). Study was pre-defined to end when 20% morbidity/mortality was reached in one group, which was reached at the end of week 10, and all mice were sacrificed at the beginning of week 11. B Blood lymphocyte subsets were quantified at the end of treatment (week 11) by flow cytometry in cenerimod- and vehicle-treated animals. Numbers in the graphs indicate the percent change versus vehicle. C Quantification of salivary gland lymphocytic subset infiltrates at the end of treatment (week 11) by flow cytometry. Cell numbers were normalized to the whole left salivary gland. Numbers in the graphs indicate the percent change versus vehicle. B,C Each data point represents the measurement of individual mice; horizontal line indicates the median, the box indicates the upper and lower quartiles and the whiskers indicate the minimum and maximum range; ***p < 0.001, ****p < 0.0001 vs. vehicle group (Mann-Whitney test). SG, salivary gland