Table 1 Least-squares mean change from baseline for patient-reported outcomes in MTX-naïve patients; filgotinib dosing regimens compared to MTX

 Week 4

− 0.64 (0.03)^***

− 0.50 (0.04)^***

− 0.56 (0.04)^***

− 0.35 (0.03)

 Week 12

− 0.91 (0.03)^***

− 0.82 (0.04)^***

− 0.80 (0.04)^***

− 0.64 (0.03)

 Week 24

− 1.00 (0.03)^***

− 0.94 (0.04)^**

− 0.91 (0.04)^*

− 0.81 (0.03)

 Week 52

− 1.03 (0.04)^***

− 0.96 (0.05)

− 0.98 (0.05)^*

− 0.87 (0.04)

 Week 4

7.3 (0.4)^***

5.8 (0.5)^**

6.4 (0.5)^***

4.1 (0.4)

 Week 12

11.6 (0.4)^***

9.6 (0.6)^**

9.4 (0.6)^*

7.9 (0.4)

 Week 24

12.8 (0.5)^***

11.5 (0.6)^*

10.8 (0.6)

9.9 (0.5)

 Week 52

13.6 (0.5)^***

12.0 (0.7)

12.2 (0.7)

10.8 (0.5)

 Week 4

4.6 (0.5)^***

3.4 (0.6)^*

4.3 (0.6)^***

1.9 (0.5)

 Week 12

5.7 (0.5)^*

5.7 (0.7)

5.4 (0.7)

4.3 (0.5)

 Week 24

5.9 (0.5)

6.3 (0.7)

5.5 (0.7)

5.7 (0.5)

 Week 52

6.5 (0.5)

6.2 (0.7)

5.8 (0.7)

5.8 (0.6)

 Week 4

7.6 (0.5)^***

6.9 (0.6)^***

7.1 (0.6)^***

4.4 (0.5)

 Week 12

10.3 (0.5)^***

9.3 (0.7)

9.8 (0.7)^*

8.1 (0.5)

 Week 24

11.3 (0.6)

11.3 (0.7)

10.3 (0.7)

10.0 (0.6)

 Week 52

12.1 (0.6)^*

11.4 (0.8)

11.6 (0.8)

10.4 (0.6)

PtGA

 Week 4

− 28 (1.2)^***

− 21 (1.6)^**

− 23 (1.6)^***

− 15 (1.2)

 Week 12

− 38 (1.3)^***

− 31 (1.7)^**

− 32 (1.7)^**

− 26 (1.3)

 Week 24

− 44 (1.3)^***

− 38 (1.7)

− 38 (1.7)

− 34 (1.3)

 Week 52

− 46 (1.4)^***

− 40 (1.8)

− 43 (1.8)^**

− 37 (1.4)

  Week 4

− 2.9 (2.0)

− 0.3 (2.8)

− 4.8 (2.7)

− 0.2 (2.1)

  Week 12

− 6.2 (1.9)

− 8.3 (2.6)

− 2.9 (2.4)

− 3.8 (1.8)

  Week 24

− 6.7 (1.7)

− 10.2 (2.3)

− 3.6 (2.1)^*

− 9.0 (1.7)

  Week 52

− 7.0 (1.8)

− 7.9 (2.5)

− 4.2 (2.4)

− 7.6 (1.9)

  Week 4

− 19.4 (2.0)^***

− 22.3 (2.8)^***

− 17.3 (2.6)^**

− 7.2 (2.1)

  Week 12

− 27.2 (2.0) ^**

− 28.2 (2.8)^*

− 25.4 (2.6)

− 19.9 (2.0)

  Week 24

− 29.8 (1.9)

− 32.2 (2.7)

− 27.5 (2.5)

− 26.8 (2.0)

  Week 52

− 33.6 (1.9)

− 30.7 (2.7)

− 32.2 (2.5)

− 30.0 (2.1)

  Week 4

− 19.0 (2.1)^***

− 21.8 (3.0)^***

− 17.1 (2.8)^**

− 6.6 (2.2)

  Week 12

− 27.6 (2.2)^**

− 28.1 (3.1)^*

− 23.4 (2.9)

− 19.5 (2.2)

  Week 24

− 30.3 (2.1)

− 30.5 (3.0)

− 24.6 (2.8)

− 26.4 (2.2)

  Week 52

− 33.4 (2.2)

− 31.2 (3.1)

− 29.8 (2.9)

− 30.3 (2.4)

  Week 4

− 23.2 (1.3)^***

− 17.8 (1.7)^*

− 19.7 (1.7)^**

− 13.5 (1.3)

  Week 12

− 32.5 (1.4)^***

− 28.1 (1.8)^*

− 30.5 (1.8)^***

− 23.6 (1.4)

  Week 24

− 36.4 (1.4)^*

− 34.6 (1.8)

− 32.7 (1.8)

− 32.3 (1.4)

  Week 52

− 39.9 (1.4)^**

− 36.4 (1.9)

− 38.4 (1.9)

− 34.5 (1.5)