The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

Xu, Bei; Xu, Guanhua; Yu, Ye; Lin, Jin

doi:10.1186/s13075-021-02678-6

Table 1 A List of microRNAs in this study

From: The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

miRNA	Experimental system	Targets	Function	References
Putative miRNAs related to PAH and SSc
miR-21	Human PAECs and PASMCs	KLF4, Smad-8	PASMC differentiation and inhibition of PASMC proliferation	[22]
miR-21	Human PAECs Rodent model of PH	BMPR2 PDCD4/caspase-3 Proliferating cell nuclear antigen cyclin D1 Bcl-xL DDAH1	PAH	[23,24,25,26]
miR-21	Fibroblasts	SMAD7	Skin fibrosis	[27]
let-7g	Human patients with SSc-PH	multiple	PAH	[28]
let-7a	Human or mouse skin fibroblasts	Type I collagen	Tissue fibrosis in the skin	[29]
miR-155	Skin of mice	CK1α SHIP-1	Dermal fibrosis	[30]
miR-29a	Skin biopsy and fibroblast samples from SSc patients and healthy controls The mouse model of bleomycin-induced skin fibrosis	Type I and type III collagen	Fibrogenesis of SSc	[31]
miR-140-5p	Marrow stromal cells	TGF-βR1	TGF-βR1 regulation Adipocyte differentiation	[32]
miRNA related to TGF-β-signaling pathway
miR-155	Lung fibroblasts and PBMC from SSc-ILD patients	Multiple	Dysregulated lung gene expression	[30]
miR-145	Normal and cutaneous scleroderma skin tissues Human fibroblasts	SMAD7 SMAD3 COL1A1	SSc	[33]
miR-145	PAH patients Human PASMCs Hypoxia-induced PAH rats	ABCA1	PASMCs proliferation and migration	[32]
miR-221-3p	Human PASMC PAH animal models	AXIN2	PASMC proliferation	[34]
miR-124	Pulmonary vascular and circulating progenitor endothelial cells isolated from patients	PTBP1	Metabolic and proliferative abnormalities in PAH ECs	[35]
miR-124	Human PASMCs Nonfamilial human PAH PAH mouse and rat models	NFATc1 CAMTA1 PTBP1 STAT3/NFAT signaling	PASMC proliferation, prodifferentiation, and survival Inflammation Pulmonary vascular remodeling	[36]
miR-143	PAH patients Human PASMCs Hypoxia-induced PAH rats	ABCA1	PASMC proliferation and migration	[32]
miR-143-3p	Calf models of PAH PAH patients Mice	Multiple	PH	[37]
miR-181a-5p	Human pulmonary artery endothelial cells PAH mice	Multiple	Vascular remodeling	[38]
miR-29 miR-29b	Mice Mice pulmonary fibroblasts	TGF-β CTGF SMAD3	Pulmonary fibrosis	[39]
miR-455-3p-1	Normal and PAH patients	FGF7	Inhibit the proliferation of PASMCs	[40]
miR-223-3p	PASMCs Rat	ITGB3	Pulmonary vascular remodeling	[41]
miR-17/92 family	HEK293 Rodent model of PH	BMPR2 STAT3	Development of PH	[42]
miRNA related to BMPR2 signaling pathway
miR-204	PASMCs in both human and rodent PAH	SHP2 NFAT	PAH-PASMC proliferation and resistance to apoptosis	[43]
miR-130/301 family	Pulmonary vessels and plasma from mammalian models and PH patients PAECs and PASMCs in mice model	PPARγ	Cell proliferation in PH	[44]
miR-130/301 family	Human PASMCs and PAECs Mice blood and lung tissue	PPARγ	Cell proliferation in PH	[45]
miR-130/301 family	Human PAECs	PPARγ LRP8	Pulmonary vascular stiffening Extracellular matrix remodeling	[46]
miR-424 (322)	The blood of PAH patients Hypoxia-induced PAECs Monocrotaline rat model of PH	SMURF1	Afterload of the right ventricle	[47]
miR-17/92 family	Human PASMCs	PDLIM5	PASMC proliferation and differentiation	[48]
miR-20a	Mice Human PASMCs	BMPR2	Prevent pulmonary arterial vascular remodeling	[49]

PAH pulmonary arterial hypertension, SSC systemic sclerosis, PAEC pulmonary artery endothelial cell, PASMC pulmonary artery smooth muscle cell, KLF4 Kruppel Like Factor 4, Smad-8 Mothers against decapentaplegic homolog 8, PH pulmonary hypertension, BMPR2 Bone Morphogenetic Protein Receptor Type II, PDCD4 Programmed Cell Death 4, Bcl-xL B cell lymphoma-extra large, DDAH1 dimethylarginine dimethylaminohydrolases 1, SMAD7 Mothers against decapentaplegic homolog 7, CK1α casein kinase 1α, SHIP-1 Src homology 2-containing inositol phosphatase-1, TGF-βR1 transforming growth factor-beta receptor type 1, SSc-ILD systemic sclerosis associated interstitial lung disease, SMAD7 Mothers against decapentaplegic homolog 7, SMAD3 Mothers against decapentaplegic homolog 3, COL1A1 Collagen Type I Alpha 1 Chain, ABCA1 ATP-binding cassette transporter A1, AXIN2 Axis inhibition protein 2, PTBP1 polypyrimidine tract-binding protein 1, NFATc1 nuclear factor of activated T cells 1, CAMTA1 calmodulin-binding transcription activator 1, STAT3 signal transducer and activator of transcription 3, NFAT nuclear factor of activated T cells, TGF-β Transforming growth factor-beta, CTGF connective tissue growth factor, FGF7 Fibroblast Growth Factor 7, ITGB3 Integrin alpha-V/beta-3, SHP2 Src homology region 2 domain-containing phosphatase-2, PPARγ Peroxisome proliferator- activated receptor gamma, LRP8 lipoprotein receptor-related protein 8, SMURF1 SMAD-specific E3 ubiquitin protein ligase 1, PDLIM5 PDZ And LIM Domain 5

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ISSN: 1478-6362

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