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Table 3 The difference of miRNA expression among cell, animal, and human PAH models presented in previous studies

From: The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

miRNA Cell model Animal model Human PAH model Consistency Reference
miR-21 Up (PAECs)
UP (Spinal fibroblasts)
UP (skin tissue)
Yes [22,23,24,25,26]
miR-29a-3p Down (hypoxia-induced pulmonary adventitial fibroblasts) N/A [77]
miR-145 Up (PASMCs under hypoxic conditions) Up (hypoxia-induced PAH rats) Up (PAH patients under hypoxic conditions) Yes [88]
miR-124 Up (Specimens of PAH patients) N/A [34]
miR-143 UP (PASMCs) UP (PAH calf models) UP (lung tissues of PAH patients) Yes [94]
miR-29 Up (Bmpr2 mutant mice lungs) Up (HPAH patients, lung tissue) Yes [39]
miR-223-3p Down (PASMCs of rat with hypoxia induction) Down (PAH rats with hypoxia induction) Yes [98]
miR-204 Down (PAH-PASMCs) Down (PAH rat model) Yes [99]
miR-130/301 family Up (PAECs, PASMCs of PAH mice) Up (hypoxic PAH mouse model) Up (PAH patients) Yes [44]
  1. Abbreviation: Up upregulation of miRNA, PAECs pulmonary artery endothelial cells, Down downregulation of miRNA, CTEPH chronic thromboembolic pulmonary hypertension, HPAH heritable pulmonary arterial hypertension, ECFCs endothelial colony-forming cells