Fig. 1

IRAK4 is upregulated in the synovium from the osteoarthritis rabbit model. A Anterior cruciate ligament resection was performed in New Zealand white rabbits (2.0–2.5 kg). B Cartilage damage was observed in rabbits 6 weeks after anterior cruciate ligament resection. Images of X-rays were obtained in rabbits 6 weeks after anterior cruciate ligament resection. C The protein expression levels of IRAK4 were detected by western blot. D Quantification of the relative protein expression via ImageJ software, β-actin was served as the internal control. E Macroscopic scoring of cartilage and K-L grading for X-ray. Data are expressed as the mean ± SD. Statistical analysis was performed by T tests, #P <0.05, compared between control and OA model groups. n=3 per group