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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Effects of adenovirus-mediated knockdown of IRAK4 on synovitis in the osteoarthritis rabbit model

Fig. 4

Ad-shIRAK4 limited OA development and delayed OA progression in the osteoarthritis rabbit model. A, B Cartilage damage was observed in rabbits 8 weeks after anterior cruciate ligament resection. the treatment with Ad-shIRAK4 significantly alleviated the cartilage damage. A, C, D Two-dimensional and three-dimensional images of micro-computerized tomography (μCT) scans were obtained 8 weeks after anterior cruciate ligament resection. A, E H&E stains were used to assess cartilage pathology. F ELISA was used to detect the level of MMP-13 in synovial fluid. Data are expressed as the mean ± SD. Statistical analysis was performed by one-way ANOVA, #P < 0.05 vs. control group; *P < 0.05, **P <0.01 vs. OA model group. n=5 per group

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