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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation

Fig. 5

Human AF fibrotic analysis at the cell level with herniation progression. A IHC staining for a–d: α-SMA, scale bar: 50 μm; e–h: MMP12, scale bar: 50 μm; i–l: macrophages (CD68) scale bar: 50 μm. B Quantification of each staining per herniation type. Data presented using dot plots, with median and interquartile range. Kruskal-Wallis test followed by corrected Dunn’s were performed. *p < 0.05; **p < 0.01. C Multivariate analysis of interaction of hernia containment level with age for α-SMA. D Correlation of α-SMA staining quantification with age for each herniation type. Data presented using dot plots with 95% confidence intervals and indication of r2 and p value for each linear regression

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