Fig. 2

Hyaluronidase treatment lowers variability in IgG levels. A–F CXCL1, IL-6, IL-8, IL-10, TNFα, and total IgG levels measured by ELISA or Luminex. Dots are RA patients, and the OA patient is represented by squares. Each point represents one aliquot. Means with SD are shown. IL-8 and total IgG were analyzed in a separate set of 8 patients compared to CXCL1, IL-6, IL-10, and TNFα. ND not detected. AD above detection limit. G–L Coefficients of variation (CV) are depicted for each set of aliquots. Each line represents one patient. n=6–8 patients. Dots are RA patients, and the OA patient is represented by open squares Wilcoxon signed rank test was performed. *P<0.05