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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis

Fig. 4

DNA methylation and RNA expression profiles of the identified hub genes in the integrating analysis. A Box plots showing the methylation level of CpGs in 6 differentially expression genes. The locations of the CpGs are shown in at the top of the boxplots. B Box plots showing the expression level of 6 differentially expression genes. For box plots, center lines represent the median, box edges represent the 25th and 75th percentiles, whisker represents the percentile ± 1.5 times interquartile range, and the dots represent the outliers. Difference between the two groups was tested by Mann–Whitney U test. *P < 0.05; **P < 0.01; ***P < 0.001. C The correlation scatter plots of expression levels against methylation levels for 6 differentially expression genes in AS cases. r, Pearson correlation coefficient. D, E The overview of genomic organization and differential methylation sites of FYN (D) and CD3G (E). The first track depicts the chromosome, with the gene region highlighted in red box. The second track represents the genome coordinate. The third track represents the transcripts of the gene. The bottom track shows the methylation level of the CpGs along the gene between AS cases and controls

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