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Table 3 Association between disease activity parameters and APOs, PB, LBW, and LFD

From: Preterm birth is strongly affected by the glucocorticoid dose during pregnancy in women complicated by systemic lupus erythematosus

 

APOs

PB

LBW

LFD

APOs (+)

(n = 35)

APOs (−)

(n = 34)

P value

PB (+)

(n = 14)

PB (−)

(n = 45)

P value

LBW (+)

(n = 23)

LBW (−)

(n = 36)

P value

LFD (+)

(n = 10)

LFD (−)

(n = 49)

P value

Achievement of LLDAS, n (%)##

1st trimester

17 (56.7)

21 (65.6)

0.60

5 (41.7)

29 (70.7)

0.09

12 (63.2)

22 (64.7)

1.00

6 (60.0)

28 (63.6)

1.00

3rd trimester

12 (46.2)

23 (67.7)

0.12

4 (28.6)

31 (68.9)

0.01*

11 (47.8)

24 (66.7)

0.18

5 (50.0)

30 (61.2)

0.73

Achievement of LLDAS without a glucocorticoid dose, n (%)##

1st trimester

20 (66.7)

27 (84.4)

0.14

5 (41.7)

36 (87.8)

<  0.01*

13 (68.4)

28 (82.4)

0.31

7 (70.0)

34 (77.3)

1.00

3rd trimester

18 (69.2)

32 (94.1)

0.01*

7 (50.0)

42 (93.3)

< 0.01*

15 (65.2)

34 (94.4)

< 0.01*

8 (80.0)

41 (83.7)

0.67

SLEDAI score#

1st trimester

2.5 ± 2.4

1.0 ± 1.4

0.01*

3.5 ± 2.9

1.1 ± 1.3

< 0.01*

2.3 ± 2.1

1.3 ± 2.0

0.03*

1.7 ± 1.4

1.7 ± 2.2

0.57

3rd trimester

1.9 ± 2.4

0.7 ± 1.2

0.02*

2.4 ± 3.0

0.8 ± 1.2

0.05

2.0 ± 2.5

0.7 ± 1.2

0.02*

1.8 ± 2.0

1.1 ± 1.9

0.16

C3, mg/dl#

1st trimester

82.4 ± 18.9

99.2 ± 21.6

0.01*

77.3 ± 19.0

95.5 ± 20.9

0.02*

80.5 ± 16.3

97.8 ± 22.3

0.01*

85.3 ± 16.7

92.2 ± 22.7

0.52

3rd trimester

94.2 ± 25.2

107.7 ± 20.0

0.09

85.5 ± 23.4

108.2 ± 20.1

<  0.01*

93.7 ± 24.9

108.3 ± 20.0

0.07

104.3 ± 31.5

102.2 ± 21.7

0.47

C4, mg/dl#

1st trimester

17.1 ± 6.7

19.6 ± 6.8

0.24

16.1 ± 9.0

19.5 ± 6.2

0.14

17.6 ± 6.3

19.4 ± 7.4

0.47

20.2 ± 7.0

18.3 ± 7.0

0.36

3rd trimester

16.7 ± 8.4

18.9 ± 6.0

0.19

15.1 ± 6.8

19.1 ± 7.0

0.11

16.9 ± 8.7

18.9 ± 5.9

0.21

20.6 ± 11.2

17.7 ± 6.3

0.51

CH50, IU/ml#

1st trimester

39.1 ± 10.6

43.0 ± 8.4

0.11

37.3 ± 10.6

41.5 ± 8.4

0.13

36.5 ± 6.6

42.7 ± 9.5

0.01*

36.9 ± 9.3

41.1 ± 8.9

0.17

3rd trimester

40.2 ± 11.5

44.6 ± 8.7

0.18

36.5 ± 10.6

45.0 ± 9.0

0.02*

40.2 ± 11.6

44.8 ± 8.6

0.14

43.8 ± 13.9

42.8 ± 9.4

0.78

Titer of anti-dsDNA antibody, IU/ml#

1st trimester

15.6 ± 44.1

7.0 ± 12.6

0.39

32.5 ± 68.5

5.7 ± 11.2

0.01*

20.7 ± 55.8

7.0 ± 12.3

0.40

30.0 ± 80.0

8.5 ± 14.5

0.94

3rd trimester

8.7 ± 17.0

3.4 ± 6.1

0.38

14.4 ± 21.4

3.1 ± 5.7

0.05

9.1 ± 17.7

3.6 ± 6.1

0.52

10.3 ± 19.6

5.1 ± 10.9

0.45

  1. Values are presented as mean ± standard deviation or number (%). #Wilcoxon rank sum test; ##Fisher’s exact test; *P < 0.05. LLDAS low lupus disease activity status, SLEDAI Systemic Lupus Erythematosus Disease Activity Index, APOs adverse pregnancy outcomes, PB preterm birth, LBW low birth weight, LFD light-for-date
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Arthritis Research & Therapy

ISSN: 1478-6362

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