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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis

Fig. 5

HCQ promotes PTEC G1/S arrest in the mice with proteinuric LN. A Representative immunohistochemical staining and quantitative analysis of renal BrdU and Ki67 in the mice with proteinuric LN. B, C Quantitative analysis of renal BrdU and Ki67 in the mice with proteinuric LN. D–G Western blotting and quantitative analysis of renal p53 and p21 in the mice with proteinuric LN subjected to I/R-induced AKI. H PI staining and flow cytometric analysis of HK-2 cells. I–K Western blotting and quantitative analysis of p53 and p21 expression in the HK-2 cells after exposure to HCQ and urinary proteins extracted from patients with LN. Each bar represents the mean ± SEM of at least 3 independent experiments, with more than 5 mice in each group at each time point. *P < 0.05, **P < 0.01, and ***P < 0.001. Original magnification × 200

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