Table 4 Patient clinical manifestations and treatment

Thrombosis

N = 167

n = 66

n = 64

 Number of thrombotic events (median, IQR)

1 [1–1]

1.5 [1–2]

p<0.001

1 [1–2]

p=0.004

  Arterial thrombosis only (n, %)

77 (46.1)

24 (36.4)

p=0.268

14 (21.9)

p=0.007

  Venous thrombosis only (n, %)

79 (47.3)

33 (50.0)

p=0.698

43 (67.2)

p=0.208

  Both arterial and venous thrombosis (n, %)

11 (6.6)

9 (13.6)

p=0.156

7 (10.9)

p=0.533

  Stroke (n, %)

48 (28.7)

22 (33.3)

p=0.894

9 (14.1)

p=0.008

  TIA (n, %)

9 (5.4)

8 (12.1)

p=0.408

3 (4.7)

p=0.581

  Limb ischemia (n, %)

6 (3.6)

6 (9.1)

p=0.783

3 (4.7)

p=0.699

  Acute myocardial infarction (n, %)

21 (12.6)

6 (9.1)

p=0.189

9 (14.1)

p=0.669

  Pulmonary embolism (n, %)

27 (16.2)

18 (27.3)

p=0.262

18 (28.1)

p=0.136

  DVT (n, %)

56 (33.5)

28 (42.4)

p=0.157

21 (32.8)

p=0.656

  Cerebral vein thrombosis (n, %)

19 (11.4)

6 (10.6)

p=0.228

14 (21.9)

p=0.045

  Retinal vessels thrombosis (n, %)

3 (1.8)

2 (3.0)

p=0.349

2 (3.1)

p=0.827

Obstetric

N = 19

n = 21

n = 29

 Number of abortions (median, IQR)

3.0 [1–5]

3 [1.5–4]

p = 0.473

3 [1–4]

p = 0.384

  More than three abortions <10 weeks (n, %)

10 (52.6)

5 (23.8)

p = 0.065

15 (48.3)

p = 0.951

  Miscarriage >10 weeks (n, %)

8 (42.1)

14 (66.7)

p = 0.123

11 (37.9)

p = 0.773

  Prematurity <34 weeks (n, %)

3 (15.8)

5 (23.8)

p = 0.529

3 (10.3)

p = 0.579

  Placental ischemia (n, %)

5 (26.3)

12 (57.1)

p = 0.054

8 (27.6)

p = 0.923

 Thrombosis patients

n = 167

n = 66

n = 64

  Indefinite anticoagulation (n, %)

54 (32.3)

40 (60.6)

p < 0.001

33 (51.6)

p = 0.008

  Vitamin K antagonist (n, %)

29 (17.4)

28 (42.4)

p < 0.001

28 (43.8)

p < 0.001

  Direct oral anticoagulant (n, %)

25 (15.0)

12 (18.2)

p = 0.546

5 (7.8)

p = 0.155

  Antiplatelet therapy (n, %)

68 (40.7)

23 (34.8)

p = 0.408

13 (20.3)

p = 0.004

  Hydroxychloroquine (n, %)

1 (0.6)

5 (7.6)

p = 0.018

5 (7.8)

p = 0.017

  Anticoagulation duration [median (months), IQR]

20.5 [11–73.8]

74.5 [23.3–114.8]

p < 0.001

61 [14–113]

p = 0.013

 Obstetric patients (during pregnancy) (n, %)

n = 18

n = 21

n = 29

  Any treatment

13 (72.2)

11 (52.4)

p = 0.209

16 (55.2)

p = 0.246

  Aspirin monotherapy

2 (11.1)

0 (0)

p = 0.998

3 (10.3)

p = 0.934

  LMWH/aspirin combination

11 (61.1)

10 (47.6)

p = 0.401

13 (44.8)

p = 0.280

  Hydroxychloroquine

6 (33.3)

3 (14.3)

p = 0.169

3 (10.3)

p = 0.063