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Table 3 Risk Factors for VTE excluding cases and controls with previous VTE

From: The association between psoriatic arthritis and venous thromboembolism: a population-based cohort study

 

Univariate Analysis

Multivariate analysis

 

+VTE

P. Value

HR

95% CI

P. Value

HR

95% CI

PsA

yes

55/5236 (1.1%)

0.051

1.36

Ref.

1.00-1.84

0.15

1.26

0.92-1.72

no

160/20750 (0.8%)

Age (Mean± SD)

 

64.60±13.04

(Without VTE 51.44 ±15.40)

<0.0001

1.08

1.07-1.09

<0.0001

1.07

1.06-1.08

Sex

Female

126/13808 (0.9%)

0.081

1.27

0.97-1.67

0.074

1.30

0.97-1.74

Socio-economic statusa

1-low

62/8672(0.7%)

 

Ref.

  

Ref.

 

2-medium

95/10707 (0.9%)

0.307

1.18

0.86-1.63

0.76

0.95

0.69-1.31

3-high

53/6184(0.9%)

0.472

1.14

0.79-1.65

0.86

0.97

0.67-1.40

BMIa

BMI<25

47/9166 (0.5%)

 

Ref.

  

Ref.

 

BMI25<30

79/9238(0.9%)

0.011

1.60

1.11-2.29

0.27

1.23

0.85-1.77

BMI30

86/7055 (1.2%)

<0.0001

2.32

1.63-3.31

0.005

1.74

1.18-2.57

Tobacco use

Yes

89/10410 (0.9%)

0.77

1.04

0.79-1.37

0.21

1.20

0.90-1.60

No

126/15576 (0.8%)

 

Ref.

  

Ref

 

Comorbidity

Cancer

       

yes

32/1582 (2.0%)

<0.0001

3.38

2.32-4.93

0.009

1.67

1.14-2.46

No

183/24404 (0.7%)

 

Ref.

  

Ref.

 

Diabetes

       

Yes

78/7126(1.1%)

<0.0001

1.99

1.50-2.63

0.62

0.92

0.67-1.27

No

137/18860 (0.7%)

 

Ref.

  

Ref.

 

IHD

       

Yes

54/2298 (2.3%)

<0.0001

4.09

3.00-5.57

0.033

1.50

1.03-2.19

No

161/ 23688 (0.7%)

 

Ref.

  

Ref.

 

CVA/TIA

       

Yes

22/1039 (2.1%)

<0.0001

3.72

2.39-5.78

0.26

1.32

0.82-2.12

No

193/24947 (0.8%)

 

Ref.

  

Ref.

 

CHF

       

Yes

13/447 (2.9%)

<0.0001

6.46

3.68-11.35

0.071

1.80

0.95-3.39

No

202/25539 (0.8%)

 

Ref.

  

Ref.

 

Hypertension

       

Yes

103/6936 (1.5%)

<0.0001

2.75

2.12-3.60

0.18

0.80

0.58-1.11

No

112/19050 (0.6%)

 

Ref.

  

Ref.

 

AF

       

Yes

12/653 (1.8%)

<0.0001

3.21

1.79-5.76

0.50

0.81

0.43-1.51

No

203/25333 (0.8%)

 

Ref.

  

Ref.

 

Vascular Disease

       

Yes

24/789 (3.0%)

<0.0001

5.48

3.58-8.39

0.011

1.83

1.15-2.92

No

191/25197 (0.8%)

 

Ref.

  

Ref.

 

COPD

       

Yes

19/1860 (1.0%)

0.14

1.43

0.89-2.29

0.96

0.99

0.61-1.59

No

196/24126 (0.8%)

 

Ref.

  

Ref.

 

CRF

       

Yes

12/666 (1.8%)

<0.0001

3.57

1.99-6.41

0.84

1.07

0.57-1.99

No

203/25320 (0.8%)

 

Ref.

  

Ref.

 
  1. aPresented data for percentages for socioeconomic status and BMI were calculated from the total number of the available data. Missing data on socioeconomic status was 5/423 (1.2%) and for BMI was 3/527 (0.6%) for PsA+controls with VTE, respectively.
  2. Abbreviations: AF Atrial fibrillation, bDMARD biologic disease-modifying anti-rheumatic drug, BMI body mass index, CHF Congestive heart failure, CI Confidence interval, COPD Chronic obstructive pulmonary disease, CRF Chronic renal failure, CVA cerebrovascular accident, HR- Hazard ratio, IHD Ischemic heart disease, PsA Psoriatic arthritis, Ref. Reference for calculation, SD Standard deviation, TIA Transient ischemic attack, VTE Venous thromboembolism.