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Table 4 Clinical data of adult patients with GSD Ia-related gout and primary gout

From: Clinical features of gout in adult patients with type Ia glycogen storage disease: a single-centre retrospective study and a review of literature

Variable

GSD Ia-related gout (n = 31)

Primary gout (n = 93)

P

Female

11 (35.5)

2 (2.2)

< 0.001*

Age, years

25 (19, 41)

34 (18, 43)

0.001*

Gout symptom onset age, years

18 (10, 29)

28 (14, 41)

0.001*

Family history of HUA

2 (6.5)

16 (17.2)

0.141

Gout symptom duration, years

5.0 ± 4.4

5.0 ± 4.5

0.997

Comorbidities

 Hypertension

0 (0)

28 (30.1)

0.001*

 Diabetes mellitus

0 (0)

6 (6.5)

0.335

 Hyperlipidaemia

31 (100)

50 (53.8)

< 0.001*

Site of first gouty attack

 Ankle

14 (45.2)

34 (36.6)

0.394

 MTP1

12 (38.7)

55 (59.1)

0.048*

 Knee

2 (6.5)

3 (3.2)

0.429

 Hand joints

2 (6.5)

1 (1.1)

0.092

 Elbows

1 (3.2)

0 (0)

0.250

Number of involved joints

3.5 ± 2.0

3.7 ± 2.9

0.053

Upper extremity involved

15 (48.4)

29 (31.2)

0.083

Presence of tophi

15 (48.4)

24 (25.8)

0.019*

Presence of renal calculi

15 (48.4)

20 (21.5)

0.004*

Proteinuria

13 (41.9)

2 (2.2)

< 0.001*

Haematuria

8 (25.8)

1 (1.1)

< 0.001*

Renal insufficiency

2 (6.5)

1 (1.1)

0.092

Maximum value of sUA, umol/L

800.5 ± 131.0

584.3 ± 112.8

0.001*

TG, mmol/L

12.4 ± 10.5

2.9 ± 1.7

0.003*

TC, mmol/L

7.1 ± 2.9

3.6 ± 1.5

0.001*

LDL-C, mmol/L

3.3 ± 1.2

2.8 ± 1.0

0.546

FBS, mmol/L

2.9 ± 0.7

5.5 ± 4.2

0.500

BMI, kg/m2

21.4 ± 4.1

27.4 ± 3.4

0.001*

  1. Abbreviation: GSD Ia glycogen storage disease type Ia, HUA hyperuricaemia, MTP1 first metatarsophalangeal, SUA serum uric acid, TG triglycerides, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, FBS fasting blood sugar, BMI body mass index
  2. *P < 0.05