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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Fig. 4

Acazicolcept (ALPN-101) protects against development of lung fibrosis in Fra-2 Tg mice model. A Left: Mean percentage of body weight change calculated between first week and sixth week of treatment. Right: Clinical score follow-up during the 6 weeks of treatment based on body weight, coat appearance, and mouse behavior. B Content of collagen in a lung fragment (μg) evaluated by Sircol assay in Fc control- and acazicolcept-treated Fra-2 Tg mice. C Left: Representative HES 4-μm lung sections of Fc control- and acazicolcept-treated mice (magnification × 8). Right: Ashcroft histological score of Fc control- and acazicolcept-treated Fra-2 Tg mice. D Left: Representative SHG images of 16-μm lung sections from Fc control- and acazicolcept-treated Fra-2 Tg mice (magnification × 25). Collagen fibers are colored in red. Right: Scoring of fibrillar collagen in lung sections from Fc control- and acazicolcept-treated mice. E Measure of right ventricular systolic pressure (mmHg) of Fc control- and acazicolcept-treated Fra-2 Tg mice after right catheterization of mice. F Left: Representative images of vessel remodelling in Fra-2 Tg lungs (magnification × 40) Right: Percentage of wall thickness in Fc control- and acazicolcept-treated Fra-2 Tg mice. Fra-2 Tg mice were divided into two groups: Fc control-treated (n = 8) and acazicolcept-treated (n = 11). Horizontal lines represent the median with range. *p < 0.05 ; **p < 0.01; by Mann-Whitney U test. ns = no significant

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