Fig. 5
Acazicolcept (ALPN-101) decreased T cell activation in lungs and spleen of Fra-2 Tg mice. A Percentages of CD4+ and CD8+ T cells in CD3+ T cells of the spleen and the lung of Fc control- and acazicolcept-treated mice. B Percentage of CD4+ or CD8+ effector memory T cells (TEM: CD62L− CD44+), naïve T (CD62L+ CD44−), and central memory T cells (TCM: CD62L+ CD44+) in spleen and lungs of Fc control- and acazicolcept-treated Fra-2 Tg mice. C Percentage of CD69- and PD-1-positive cells within CD4+ or CD8+ subsets in spleen and lungs of Fc control- and acazicolcept-treated Fra-2 Tg mice. D Spearman correlation between CD69 and PD-1 expression on lung CD4/CD8 T cells evaluated by flow cytometry and lung collagen content evaluated by Sircol assay. Flow cytometry analysis was performed on 4 spleen/lungs from Fc control-treated mice and on 6 spleen/lungs of acazicolcept-treated Fra-2 Tg mice. Horizontal lines represent the median with range *p < 0.05; **p < 0.01; ***p < 0.001 by Mann-Whitney U test. ns = not significant