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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Fig. 6

Acazicolcept (ALPN-101) serum exposure. A Left : Measurement of acazicolcept concentrations in HOCL-treated mouse serum 24 h after the 8th (n = 8) or the 13th dose (n = 8). Right: Measurement of acazicolcept concentrations in Fra-2 Tg mouse serum collected 24 hours after the 10th (n = 4) or the 13th dose (n = 6). Right: B Percentage of anti-human IgG Fc-binding cells among CD4+ or CD8+ cells from spleen and lungs of Fc control- (n = 4) or acazicolcept (n = 6)-treated mice as measured by flow cytometry. C Percentage of ICOS- and CD28-positive cells in CD4+ or CD8+ T cells from the lungs and spleen of Fc control- (n = 4) and acazicolcept (n = 6)-treated mice as measured by flow cytometry. Horizontal lines represent the median with range *p < 0.05; **p < 0.01; by Mann-Whitney U test

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Arthritis Research & Therapy

ISSN: 1478-6362

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