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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis

Fig. 2

Co-abundance networks of consensus genera in (A) oral and (B) fecal microbial communities based on SparCC correlation [54]. Node colors indicate class level taxonomy, the edge width and color between nodes show the strength and direction of the bacterial correlations. Node shapes highlight indicator genera [49] for a healthy or CRMO-associated microbial community (■—healthy, ▲—CRMO), or bacteria associated to disease relapse (★—relapse, ✦—no relapse). Networks (C) and (D) highlight the position of genera belonging to the HACEK group in the co-abundance networks (★—HACEK). Barplots show the top 30 most central bacteria in oral (E) and fecal (F) bacterial consensus genus networks (node betweenness; see Table S3). Bar colors indicate bacterial classification at the class level. Names highlighted in red indicate higher than average centrality values according to network permutation tests. Additionally, significant indicator species associations are added above the names and potential HACEK membership is indicated next to genus names (/STAR/)

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