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Table 2 Baseline predictors for progression to IA in anti-CCP+ individuals

From: Prioritising referrals of individuals at-risk of RA: guidance based on results of a 10-year national primary care observational study

Predictor Non-progressors (n = 83) Progressors to
IA (n = 68)
Univariable
OR (95% CI) P-value
Multivariable
OR (95% CI) P-value
Mean age (SD; range) 50 (15.65; 18–77) 54 (14.39; 23–83) 1.01 (0.99–1.03) P = 0.136 0.95 (0.95–1.02) P = 0.504
Female (%) 66 56 0.64 (0.33–1.24) P = 0.193 0.56 (0.21–1.45) P = 0.234
CCP high level (%) 45 90 10.83 (4.43–26.48) P < 0.001 9.42 (3.13–28.30) P < 0.001
Family with RA (%) 58 47 0.64 (0.34–1.23) P = 0.188 0.56 (0.24–1.34) P = 0.198
Ever smoked (%) 55 72 2.07 (1.04–4.11) P = 0.037 2.37 (0.96–5.83) P = 0.060
Neck (%) 30 22 0.65 (0.72–3.19) P = 0.266 0.39 (0.13–1.13) P = 0.086
Shoulders (%) 47 56 1.18 (0.13–1.37) P = 0.277 0.90 (0.35–2.36) P = 0.844
Elbows (%) 28 27 0.93 (0.45–1.93) P = 0.865 0.93 (0.33–2.62) P = 0.894
Wrists (%) 43 66 2.55 (1.31–4.96) P = 0.006 1.28 (0.49–3.36) P = 0.607
Hands (%) 47 81 4.77 (2.27–10.02) P < 0.001 2.74 (1.03–7.27) P = 0.043
Thumbs (%) 29 40 1.61 (0.82–3.19) P = 0.164 1.34 (0.44–4.06) P = 0.599
Back (%) 23 13 0.51 (0.21–1.22) P = 0.133 0.68 (0.20–2.25) P = 0.532
Hips (%) 31 29 0.91 (0.45–1.83) P = 0.799 1.33 (0.51–3.46) P = 0.557
Knees (%) 46 56 1.50 (0.78–2.85) P = 0.218 1.08 (0.44–2.69) P = 0.855
Ankles (%) 30 32 1.11 (0.55–2.21) P = 0.768 0.80 (0.27–2.41) P = 0.701
Feet (%) 29 62 3.97 (2.00–7.85) P < 0.001 4.10 (1.59–10.54) P = 0.003