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Table 3 Baseline predictors for progression to IA in anti-CCP− individuals

From: Prioritising referrals of individuals at-risk of RA: guidance based on results of a 10-year national primary care observational study

Predictor Non-progressors (n = 5587) Progressors to IA (n = 53) Univariable
OR (95% CI) P-value
Multivariable
OR (95% CI) P-value
Mean age (SD; range) 53 (14.7; 16–91) 60 (13.62; 30–82) 1.04 (1.02–1.06) P < 0.001 1.04 (1.02–1.07) P < 0.001
Female (%) 72 58 0.54 (0.31–0.94) P = 0.030 0.67 (0.35–1.28) P = 0.229
Family with RA (%) 38 33 0.758 (0.42–1.35) P = 0.349 1.14 (0.59–2.19) P = 0.683
Ever smoked (%) 38 43 1.25 (0.69–2.28) P = 0.462 1.11 (0.60–2.05) P = 0.730
Neck (%) 30 29 1.03 (0.57–1.8) P = 0.932 0.62 (0.29–1.30) P = 0.202
Shoulders (%) 41 59 1.99 (1.15–3.45) P = 0.014 1.95 (0.98–3.86) P = 0.056
Elbows (%) 29 40 1.58 (0.91–2.75) P = 0.104 1.32 (0.67–2.59) P = 0.413
Wrists (%) 38 47 1.43 (0.83–2.46) P = 0.193 1.18 (0.60–2.31) P = 0.625
Hands (%) 53 76 2.67 (1.43–5.02) P = 0.002 2.51 (1.17–5.39) P = 0.018
Thumbs (%) 36 49 1.70 (0.99–2.92) P = 0.054 1.23 (0.63–2.41) P = 0.541
Back (%) 33 25 0.66 (0.35–1.23) P = 0.190 0.66 (0.31–1.41) P = 0.279
Hips (%) 36 28 0.69 (0.38–1.26) P = 0.226 0.57 (0.28–1.17) P = 0.127
Knees (%) 55 72 2.07 (1.14–3.77) P = 0.018 3.03 (1.47–6.25) P = 0.003
Ankles (%) 30 23 0.68 (0.36–1.29) P = 0.239 0.55 (0.25–1.21) P = 0.140
Feet (%) 34 42 1.37 (0.79–2.38) P = 0.256 1.04 (0.52–2.06) P = 0.910