From: Secular trends in cryoglobulinemia mortality in the USA in the era of direct-acting antivirals
1999–2003 | 2004–2008 | 2009–2013 | 2014–2018 | 1999–2018 | 2014–2018/2009–2013 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | % | No. | % | No. | % | No. | % | No. | % | PMR | 95% CI | |
Cryoglobulinemia with hepatitis C virus | ||||||||||||
Total | 125 | 32.7 | 99 | 32.5 | 118 | 39.1 | 81 | 26.1 | 423 | 32.6 | 0.67 | (0.50–0.89) |
Sex | ||||||||||||
Men | 62 | 36.9 | 60 | 44.1 | 67 | 45.0 | 50 | 35.5 | 239 | 40.2 | 0.79 | (0.55–1.14) |
Women | 63 | 29.4 | 39 | 23.1 | 51 | 33.3 | 31 | 18.3 | 184 | 26.1 | 0.55 | (0.35–0.86) |
Age (years) | ||||||||||||
20–54 | 74 | 64.9 | 55 | 58.5 | 23 | 47.9 | 11 | 40.7 | 163 | 57.6 | 0.85 | (0.41–1.74) |
55–64 | 19 | 31.1 | 28 | 40.6 | 70 | 61.4 | 41 | 42.7 | 158 | 46.5 | 0.70 | (0.47–1.02) |
65+ | 32 | 15.5 | 16 | 11.3 | 25 | 17.9 | 29 | 15.5 | 102 | 15.1 | 0.87 | (0.51–1.48) |
Cryoglobulinemia with autoimmune disease (ICD-10 codes) | ||||||||||||
Autoimmune disease (M30–M36) | 16 | 4.2 | 13 | 4.3 | 8 | 2.6 | 13 | 4.2 | 50 | 3.8 | 1.58 | (0.66–3.82) |
Systemic lupus erythematosus (M32) | 6 | 1.6 | 3 | 1.0 | 2 | 0.7 | 4 | 1.3 | 15 | 1.2 | 1.95 | (0.36–10.64) |
Sjogren’s syndrome (M350) | 6 | 1.6 | 5 | 1.6 | 3 | 1.0 | 6 | 1.9 | 20 | 1.5 | 1.95 | (0.49–7.79) |
Other autoimmune disease | 5 | 1.3 | 6 | 2.0 | 3 | 1.0 | 5 | 1.6 | 19 | 1.5 | 1.62 | (0.39–6.79) |
Sex | ||||||||||||
Men | 4 | 2.4 | 1 | 0.7 | 4 | 2.7 | 2 | 1.4 | 11 | 1.9 | 0.53 | (0.10–2.88) |
Women | 12 | 5.6 | 12 | 7.1 | 4 | 2.6 | 11 | 6.5 | 39 | 5.5 | 2.49 | (0.79–7.82) |
Age (years) | ||||||||||||
20–54 | 4 | 3.5 | 4 | 4.3 | 2 | 4.2 | 3 | 11.1 | 13 | 4.6 | 2.67 | (0.45–15.96) |
55–64 | 5 | 8.2 | 3 | 4.3 | 4 | 3.5 | 4 | 4.2 | 16 | 4.7 | 1.19 | (0.30–4.75) |
65+ | 7 | 3.4 | 6 | 4.2 | 2 | 1.4 | 6 | 3.2 | 21 | 3.1 | 2.25 | (0.45–11.13) |