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Table 2 Numbers of people who died with mention of cryoglobulinemia and hepatitis C virus and those died with mention of cryoglobulinemia and systemic autoimmune disease in the USA, 1999–2018

From: Secular trends in cryoglobulinemia mortality in the USA in the era of direct-acting antivirals

 

1999–2003

2004–2008

2009–2013

2014–2018

1999–2018

2014–2018/2009–2013

No.

%

No.

%

No.

%

No.

%

No.

%

PMR

95% CI

Cryoglobulinemia with hepatitis C virus

Total

125

32.7

99

32.5

118

39.1

81

26.1

423

32.6

0.67

(0.50–0.89)

Sex

 Men

62

36.9

60

44.1

67

45.0

50

35.5

239

40.2

0.79

(0.55–1.14)

 Women

63

29.4

39

23.1

51

33.3

31

18.3

184

26.1

0.55

(0.35–0.86)

Age (years)

 20–54

74

64.9

55

58.5

23

47.9

11

40.7

163

57.6

0.85

(0.41–1.74)

 55–64

19

31.1

28

40.6

70

61.4

41

42.7

158

46.5

0.70

(0.47–1.02)

 65+

32

15.5

16

11.3

25

17.9

29

15.5

102

15.1

0.87

(0.51–1.48)

Cryoglobulinemia with autoimmune disease (ICD-10 codes)

Autoimmune disease (M30–M36)

16

4.2

13

4.3

8

2.6

13

4.2

50

3.8

1.58

(0.66–3.82)

Systemic lupus erythematosus (M32)

6

1.6

3

1.0

2

0.7

4

1.3

15

1.2

1.95

(0.36–10.64)

Sjogren’s syndrome (M350)

6

1.6

5

1.6

3

1.0

6

1.9

20

1.5

1.95

(0.49–7.79)

Other autoimmune disease

5

1.3

6

2.0

3

1.0

5

1.6

19

1.5

1.62

(0.39–6.79)

Sex

 Men

4

2.4

1

0.7

4

2.7

2

1.4

11

1.9

0.53

(0.10–2.88)

 Women

12

5.6

12

7.1

4

2.6

11

6.5

39

5.5

2.49

(0.79–7.82)

Age (years)

 20–54

4

3.5

4

4.3

2

4.2

3

11.1

13

4.6

2.67

(0.45–15.96)

 55–64

5

8.2

3

4.3

4

3.5

4

4.2

16

4.7

1.19

(0.30–4.75)

 65+

7

3.4

6

4.2

2

1.4

6

3.2

21

3.1

2.25

(0.45–11.13)

  1. PMR proportionate mortality ratio, 95% CI 95% confidence interval, ICD-10 codes International Classification of Diseases, Tenth Revision