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Table 2 Independent association between rheumatoid arthritis (RA) and incidence of cardiovascular events in the whole GAZEL cohort

From: Rheumatoid arthritis, as a clinical disease, but not rheumatoid arthritis-associated autoimmunity, is linked to cardiovascular events

Variable

Univariable analysis

Multivariable analysis

HR (95% CI)

p

HR (95% CI)

p

Confirmed RA

3.11 (1.17–8.32)

0.02

3.03 (1.13–8.11)

0.03

Gender (male)

2.37 (1.92–2.94)

< 0.001

1.85 (1.50–2.34)

< 0.001

Tobacco consumption (≥ 20 PY)

1.84 (1.58–2.15)

< 0.001

1.54 (1.31–1.80)

< 0.001

High blood pressure

1.78 (1.54–2.06)

< 0.001

1.51 (1.30–1.76)

< 0.001

Diabetes

1.72 (1.39–2.13)

< 0.001

1.25 (1.00–1.56)

0.05

Dyslipidemia

1.40 (1.21–1.62)

< 0.001

1.19 (1.03–1.38)

0.02

Obesity (BMI ≥ 30)

1.49 (1.24–1.79)

< 0.001

1.17 (0.971.43)

0.11

Parental antecedent of myocardial infarction

1.17 (0.931.47)

0.18

1.11 (0.881.40)

0.37

Age (years)

1.09 (1.07–1.12)

< 0.001

1.06 (1.04–1.09)

< 0.001

Alcohol consumption

0.83 (0.68–1.02)

0.07

0.72 (0.58–0.88)

0.001

  1. Analysis consisted in piecewise-exponential Poisson regression to assess longitudinal data from 2005 to 2014