Skip to main content

Table 4 Association of ACPA and/or RF positivity (without RA) with incident CV events in subjects with plasma sample available

From: Rheumatoid arthritis, as a clinical disease, but not rheumatoid arthritis-associated autoimmunity, is linked to cardiovascular events

Variable

Univariable analysis

Multivariable analysis

HR (95% CI)

p

HR (95% CI)

p

Presence of ACPA

2.07 (0.84–5.11)

0.12

1.52 (0.47–4.84)

0.48

Presence of RF

1.55 (0.49–4.90)

0.46

1.15 (0.55–2.40)

0.70

Other factors

Gender (male)

1.86 (0.90–3.87)

0.09

1.20 (0.57–2.55)

0.63

Age (years)

1.17 (1.09–1.26)

< 0.001

1.14 (1.06–1.23)

< 0.001

High blood pressure

2.19 (1.40–3.42)

< 0.001

1.87 (1.17–2.96)

0.008

Diabetes

1.26 (0.55–2.90)

0.59

0.84 (0.35–2.01)

0.70

Dyslipidemia

1.57 (1.01–2.45)

0.50

1.42 (0.90–2.24)

0.13

Obesity (BMI ≥ 30)

1.14 (0.57–2.29)

0.71

0.87 (0.42–1.78)

0.70

Tobacco consumption (≥ 20 PY)

2.21 (1.39–3.50)

< 0.001

1.87 (1.16–3.02)

0.01

Alcohol consumption

0.91 (0.51–1.62)

0.75

0.78 (0.43–1.39)

0.39

Parental antecedent of myocardial infarction

1.01 (0.47–2.20)

0.97

0.85 (0.39–1.86)

0.69

  1. This analysis only concerned the subjects with available blood sample for ACPA/RF testing, without RA (N = 1609)