Fig. 4

Proportions of patients achieving normative values in PROs up to month 12. Proportions of patients who met or exceeded population normative values for a FACIT-F total score and b–i SF-36 domain scores, to month 12 across treatment groups^a pooled from Phase 3 ORAL Scan, ORAL Standard, and ORAL Sync study datasets (full analysis set). ^aAll treatments were administered in combination with background conventional synthetic disease-modifying antirheumatic drugs. Patients were not normative at baseline. ^* p < 0.05, ^** p < 0.01, and ^*** p < 0.001 for tofacitinib and adalimumab vs placebo; ^† p < 0.05 and ^†† p < 0.01 for tofacitinib vs adalimumab. ADA, adalimumab; BID, twice daily; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; PRO, patient-reported outcome; Q2W, once every 2 weeks; SE, standard error; SF-36, Short Form-36 Health Survey