Fig. 6

Peripheral CD56^dimCD57⁺ NK cells from SLE patients exhibited impaired cytotoxicity in response to activated CD4⁺ T cells. A Cytoxicity assay of CD4⁺ T cells in response to NK cell subsets (n = 3). B Cytoxicity assay of CD4⁺ T cells in response to CD56^dimCD57⁺ NK cells from SLE patients and HCs (n = 3). C Comparison of ICOS expression on CD4⁺ T cells from SLE patients (n = 10) and HCs (n = 9). D Comparison of PD-1 expression on CD4⁺ T cells from SLE patients (n = 10) and HCs (n = 10). E Comparison of ICOS expression on CD4⁺ T cells after co-culture with NK subsets (n = 4). F The correlation of ICOS expression on CD4⁺ T cells and CD56^dimCD57⁺ NK cell percentage in SLE patients (n = 10). G The correlation of PD-1 expression on CD4⁺ T cells and CD56^dimCD57⁺ NK cell percentage in SLE patients (n = 10). ICOS: Inducible T cell costimulator; PD-1: programmed death 1. (* P < 0.05)