Fig. 2

A Multiple hypotheses corrected p-values for each antigen in every pairwise comparison using Tukey’s test. This heatmap shows the magnitude of the fold changes between conditions and their statistical significance for each comparison. The color of each circle represents the fold change between conditions, where red indicates a high fold change, light yellow a low fold change, and blue indicates negative fold change. The size of each circle is proportional to the statistical significance of the difference between conditions, where larger circles represent more significant differences. A white cell represents antigens that were not showing a statistically significant difference between conditions based on the FDR threshold of 5%. B Boxplots of expression of each significant antigen in each of the four groups. Boxes represent inter-quartiles (25% and 75% percentile), and whiskers represent maximum and minimum values. SSc, systemic sclerosis; PAH, pulmonary arterial hypertension