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Table 1 Baseline characteristics of patient groups

From: Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension

 

Healthy

PAH

High risk

Low risk

pvalue

n=20

n=81

n=71

n=10

Age, mean (std) (n)

59.7 (8.9) (20)

58 (11.3) (79)

60.1 (10.8) (71)

52.3 (10.7) (10)

0.20

Sex

    

0.18

 Female

15 (75.0)

59 (74.7)

62 (87.3)

9 (90.0)

 

 Male

5 (25.0)

20 (25.3)

9 (12.7)

1 (10.0)

 

Race/ethnicity

    

<.0001

 Asian/Pacific Islander

 

1 (1.3)

1 (1.4)

3 (30.0)

 

 Black

 

12 (15.2)

2 (2.8)

0

 

 Caucasian

 

64 (81.0)

60 (84.5)

3 (30.0)

 

 Hispanic

 

2 (2.5)

5 (7.0)

3 (30.0)

 

 Native American

 

0

2 (2.8)

0

 

 Other Ethnic Origin

 

0

1 (1.4)

1 (10.0)

 

SSc subtype

    

0.39

 Diffuse

 

20 (25.0)

15 (21.1)

5 (50.0)

 

 Limited

 

57 (71.2)

54 (76.1)

5 (50.0)

 

 Unclassified

 

3 (3.8)

2 (2.8)

0

 

Antibody

    

0.1433

 Mixed or other

 

15 (19.0)

13 (18.6)

0

 

 Scl 70

 

13 (16.5)

15 (21.4)

2 (20.0)

 

 U1RNP

 

3 (3.8)

1 (1.4)

0

 

 Centromere

 

20 (25.3)

15 (21.4)

6 (60.0)

 

 Isolated nucleolar

 

20 (25.32)

13 (18.57)

0

 

 Negative

 

3 (3.8)

9 (12.9)

2 (20.0)

 

 RNA polymerase III

 

5 (6.3)

4 (5.7)

0

 

FVC, median (range) (n)

 

71.2 (27.1–104.8) (69.0)

85.2 (32.5–130.6) (64.0)

96.0 (84.0–112.0) (10.0)

<.0001

DLCO, median (range) (n)

 

37.0 (9.9–90.7) (67)

50.4 (10.1–94.2) (60)

98.5 (80.0–128.0) (10)

<.0001

RVSP, median (range) (n)

 

50.5 (17.0–120.0) (68)

38.5 (23.0–80.0) (60)

28.0 (18.0–35.0) (7)

<.0001

Disease duration, years, median (range) (n)

     

 Raynaud’s symptom

 

10.2 (0.9–45.1) (75)

10.7 (0.4–49.2) (64)

7.3 (1.5–33.7) (9)

0.4951

 Non-Raynaud’s symptom

 

8.7 (0.0–33.0) (74)

9.3 (0.1–40.9) (66)

5.1 (1.3–15.3) (9)

0.1644

  1. SSc systemic sclerosis, PAH pulmonary arterial hypertension, ANA antinuclear antibodies, FVC forced vital capacity, DLCO diffusing capacity for carbon monoxide, RVSP right ventricular systolic pressure