Fig. 1

Standardized estimated difference between patients with flare versus no flare for clinical and MRI variables. Data are shown for patients with and without flare at A WD+6months (mo) and B WD+12mo. Data from WD (or at baseline for age, weight, and duration of rheumatoid arthritis [RA]) were standardized to have a mean equal to zero and a standard deviation (SD) equal to one and were compared by the estimated differences between flare versus no flare groups. Vertical line indicates limit of effect: positive data indicate effect, negative data or data that cross 0 indicate absence of effect. P values of comparison were calculated from Student’s t test; values in bold indicate statistical significance. *Number of subjects with WD data available. ^†Higher SF-36 scores denote improvement in quality of life. ^‡Synovitis score + edema score. ^§Synovitis score + 2x edema score. CI confidence interval, CRP C-reactive protein, DAS28 Disease Activity Score in 28 joints, HAQ-DI Health Assessment Questionnaire–Disability Index, OR odds ratio, PGA Physician Global Assessment, PRO patient-reported outcomes, PtGA Patient Global Assessment, SF36 Short Form-36, SJC(28) Swollen 28-Joint Count, TJC(28) Tender 28-Joint Count, VAS visual analog scale, WD withdrawal