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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis

Fig. 4

MCP-1 production in the monocyte subsets following treatment with pembrolizumab in SFMCs from arthritis patients (n = 4, 2 SpA patients and 2 PsA patients). A Representative dotplots of MCP-1 production in classical monocytes. B Representative dot plots of MCP-1 production in intermediate monocytes. C Upper panel: Frequency of MCP-1+ cells in classical monocytes in each culture. Lower panel: Data were normalized and expressed as ratios. D Upper panel: Frequency of MCP-1+ cells in intermediate monocytes in each culture. Lower panel: Data were normalized and expressed as ratios. All data are expressed as median with interquartile range. Log-transformed ratios were analyzed with the paired Student’s t-test. *P-value < 0.05, **P-value < 0.01, ***P-value < 0.001. UT, untreated; Pembro, pembrolizumab

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Arthritis Research & Therapy

ISSN: 1478-6362

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