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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Tumor necrosis factor alpha neutralization attenuates immune checkpoint inhibitor-induced activation of intermediate monocytes in synovial fluid mononuclear cells from patients with inflammatory arthritis

Fig. 5

Production of different pro-inflammatory cytokines by SFMC cultures following treatment with pembrolizumab (n = 11). Production of TNF, IL-6, IFN-γ, IL-12p70, IL-10, IL-1β, IL-2, IL-13, and IL-4 in SFMCs from arthritis patients cultured for 48 h untreated (UT) or treated with pembrolizumab (Pembro) (8 RA patients, 2 PsA patients, and 1 SpA patient). Data were normalized to untreated cultures and expressed as ratios. Cytokine measurements were excluded if levels were above or below the detection range. All data are expressed as median with interquartile range. Log-transformed ratios were analyzed with the paired Student’s t-test. *P-value< 0.05, **P-value < 0.01, ***P-value< 0.001

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Arthritis Research & Therapy

ISSN: 1478-6362

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