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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis

Fig. 8

GW4869 injection reversed changed mRNA expression in condylar cartilage of rats with TMJ OA induced by UAC stimulation. A mRNA expression of Col2a1 and Aggrecan was significantly increased in the TMJs of UAC rats with GW4869 injection (n = 6). B mRNA expression of Mmp13, Runx2, and Osteocalcin was significantly decreased in the TMJs of UAC rats with GW4869 injection (n = 6). UAC, unilateral anterior crossbite group; UAC+GW4869, unilateral anterior crossbite group with GW4869 injection; 8w, 8 weeks; 12w, 12 weeks. All data are presented as means ± SD. The data of compared groups were from the populations of Gaussian distribution and consistent with homogeneity of variance. Comparisons between the UAC and UAC + GW4869 group of the same timepoint were performed by Student’s t-test. **P < 0.01, compared with the age-matched UAC group

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