Fig. 9

Exosome injection-induced degenerative lesion in condylar cartilage of control rats. A mRNA expression of Col2a1 and Aggrecan was significantly decreased in the TMJs of control rats with exosome injection (n = 6). B mRNA expression of Mmp13, Runx2, and Osteocalcin was significantly increased in the TMJs of control rats with exosome injection (n = 6). Control, control group; Control + Exosome, control group with exosome injection; 8w, 8 weeks; 12w, 12 weeks. All data are presented as means ± SD. The data of compared groups were from the populations of Gaussian distribution and consistent with homogeneity of variance. Comparisons between the control and control + exosome group of the same timepoint were performed by Student’s t test. **P < 0.01, compared with the age-matched control group