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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome

Fig. 4

IIM/ASSD patients diagnosed with ILD and arthritis and less skin involvement harbor more reactive anti-Jo1 autoantibodies. A–D Percentage of IIM/ASSD patients distributed according to anti-HisRS full-length (HisRS-FL) reactivity levels, clinical diagnosis, and clinical manifestations. The anti-HisRS-FL reactivity displayed was measured in total anti-Jo1+ IgG purified from serum. Numbers on top of the bars represent the percentage of patients in the group. Anti-HisRS-FL−, anti-Jo1 IIM/ASSD-negative patients; anti-HisRS-FL+ +, anti-Jo1 IIM/ASSD-positive patients with low to moderate reactivity (0.5–100 ng/mL); anti-HisRS-FL+ ++, anti-Jo1 IIM/ASSD-positive patients with high HisRS reactivity (> 100 ng/mL). Antibody titers were calculated from OD (450 nm) using the standard curve in Supplementary Fig. 3B. IIM, idiopathic inflammatory myopathies; ILD, interstitial lung disease; ASSD, anti-synthetase syndrome. Statistical differences among groups are displayed in Supplementary Table 3

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Arthritis Research & Therapy

ISSN: 1478-6362

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