Table 1 Baseline characteristics of the included patients
Variables | N = 2235 |
|---|---|
Age (years) (median, range) | 65, 19–98 |
<50 (%) | 381 (17%) |
50–64 (%) | 699 (31%) |
65–74 (%) | 767 (34%) |
≥ 75 (%) | 388 (17%) |
Sex (male, female) (%) | 406 (18%), 1829 (82%) |
Body mass index (median, range) | 22, 13–42 |
Job (yes, no) (%) | 957 (45%), 1179 (55%) |
Disease duration (years) (median, range) | 11, 0–70 |
Steinbrocker stage 1, 2, 3, 4 (%) | 612 (27%), 709 (32%), 305 (14%), 560 (25%) |
Comorbidities | |
Cardiovascular disorder | 106 (5%) |
Pulmonary disorder | 193 (9%) |
Osteoporosis | 285 (23%) |
TJC (median, range) | 0, 0–28 |
SJC (median, range) | 0, 0–13 |
RF (positive, negative) | 1574 (73.7%), 563 (26.4%) |
ACPA (positive, negative) | 1541 (78.9%), 411 (21.1%) |
CRP (mg/dL) (median, range) | 0.11, 0–21.9 |
ESR 1 h (mm) (median, range) | 14, 0–144 |
Treatment | |
Medication | |
Prednisolone use (yes, no) (%) | 896 (40%), 1339 (60%) |
Dose (mg) (median, range) | 3, 0–18 |
Methotrexate use (yes, no) (%) | 1614 (72%), 621 (28%) |
Dose (mg) (median, range) | 8, 2–20 |
b/tsDMARDs use (yes, no) (%) | 697 (31%), 1538 (69%) |
History of musculoskeletal surgery (yes, no) (%) | 463 (21%), 1769 (79%) |
Prosthesis | 246 (11%) |
Postoperative < 5 years, ≥ 5 years | 77 (31%), 169 (69%) |
Spine surgery | 48 (2%) |
Postoperative < 5 years, ≥ 5 years | 15 (31%), 33 (69%) |
Others* | 186 (8%) |
Postoperative < 5 years, ≥ 5 years | 61 (33%), 110 (59%) |
Pain VAS (cm) (median, range) | 1.2, 0–10 |
General VAS (cm) (median, range) | 0.9, 0–10 |
Physician VAS (cm) (median, range) | 0.5, 0–10 |
DAS28-ESR | 2.3, 0–7.1 |
Remission (≤ 2.6) | 1298 (61%) |
Low disease activity (> 2.6, ≤ 3.2) | 788 (18%) |
Moderate disease activity (> 3.2, ≤ 5.1) | 188 (20%) |
High disease activity (> 5.1) | 16 (1%) |
SDAI | 2.9, 0–43.3 |
Remission (≤ 3.3) | 1175 (54%) |
Low disease activity (> 3.3, ≤ 11) | 788 (36%) |
Moderate disease activity (> 11, ≤ 26) | 188 (9%) |
High disease activity (> 26) | 16 (1%) |
CDAI | 2.7, 0–39.5 |
Remission (≤ 2.8) | 1113 (51%) |
Low disease activity (> 2.8, ≤ 10) | 853 (39%) |
Moderate disease activity (> 10, ≤ 22) | 184 (8%) |
High disease activity (> 22) | 18 (1%) |
mHAQ (median, range) | 0.1, 0–3.0 |
EQ5D score (median, range) | 0.8, 0.03–1.0 |