Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Table 5 Experimental animal models for the research of OA and aging

Exp. animal models for OA	Refs	Exp. animal models for aging	Refs
Spontaneous model of OA		Transgenic mouse strains
STR/ort mice	[132]	p16^LUC knock-in mice	[133]
SAMP8 mice	[134]	Cdkn2a^luc/luc mice	[134]
Surgically induced OA models		p16-3MR transgenic mice	[83]
ACLT	[135]	SAMP8 mice	[136]
DMM	[137]	D-Galactose-induced model	[138]
Transgenic and inbred mouse strains		Slc25a46- knockout mice	[139]
ADAMTS5-knockout mice	[140]
SIRT1-knockout mice	[87]
JNK-knockout mice	[36]
AMPK α1-knockout mice	[141]
Pitx1-knockout mice	[71]
Chemically induced models
Injections of MIA	[77, 142, 143]

SAMP senescence-accelerated mouse-prone, ACLT anterior cruciate ligament transection, DMM destabilization of the medial meniscus, SIRT1 Sirtuin 1, JNK Jun N-terminal kinases, AMPK AMP-activated protein kinase, Pitx1 pituitary homeobox 1, MIA, monosodium iodoacetate

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