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Table 3 Safety cohort biomarkers for each group at days 3 and 21

From: Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model

Target

Concentration (pg/mL)

Day 3

Day 21

Vehicle control

50 μL ASA

Vehicle control

50 μL ASA

IFN-γ

NT

NT

0.83 ± 0.25

2.58 ± 1.10^

IL-1α

1.19 ± 1.19

41.32 ± 14.88*

74.25 ± 19.37

136.30 ± 34.77

MCP-1

NT

NT

21.76 ± 1.99

46.21 ± 7.91^

bNGF

4.56 ± 1.25

22.29 ± 6.70*

7.72 ± 3.47

4.26 ± 2.71

  1. Average ± standard error reported; n = 5–10 per group. *p < 0.05, ^p < 0.001 by Dunnett’s multiple comparisons test to vehicle control. Targets not included in the table were not significant compared to vehicle control. ASA amniotic suspension allograft, NT not tested