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Table 1 Baseline demographics and disease characteristics for patients enrolled in studies of IV golimumab in RA, PsA, and AS*

From: Pooled safety results across phase 3 randomized trials of intravenous golimumab in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

 

RA trial

PsA trial

AS trial

Placebo

Golimumab

Placebo

Golimumab

Placebo

Golimumab

Patients, N

197

395

239

241

103

105

Demographics and disease characteristics

 Mean age, years (range)

51.4 (19, 78)

51.9 (18, 83)

46.7 (18, 79)

45.7 (19, 69)

39.2 (20, 67)

38.4 (19, 64)

 Male, n (%)

40 (20.3)

69 (17.5)

121 (50.6)

128 (53.1)

77 (74.8)

86 (81.9)

 BMI, kg/m2

27.0 (5.7)

26.8 (5.5)

28.9 (6.2)

28.9 (6.4)

26.8 (6.4)

27.2 (5.9)

 Disease duration, years

7.0 (7.2)

6.9 (7.0)

5.3 (5.9)

6.2 (6.0)

5.5 (5.9)

5.6 (6.6)

 Swollen Joint count (0–66)

14.8 (8.5)

15.0 (8.2)

14.1 (8.2)

14.0 (8.4)

–

–

 Tender joint count (0–68)

25.9 (14.1)

26.4 (13.9)

26.1 (14.4)

25.1 (13.8)

–

–

 CRP, mg/dL

2.2 (1.9)

2.8 (2.9)

2.0 (2.0)

1.9 (2.5)

1.9 (1.7)

2.0 (1.8)

 BASDAI, N

–

–

53**

56**

103

105

  Score

–

–

6.4 (1.9)

6.5 (1.8)

7.1 (1.2)

7.0 (1.2)

 Methotrexate, n (%)

197 (100)

395 (100)

173 (72.4)

163 (67.6)

21 (20.4)

16 (15.2)

  Dose, mg/week

16.6 (2.8)

16.8 (2.9)

14.9 (4.8)

14.8 (4.7)

13.7 (5.0)

16.7 (4.9)

 Oral corticosteroids, n (%)

134 (68.0)

251 (63.5)

67 (28.0)

66 (27.4)

23 (22.3)

32 (30.5)

  Dose***, mg/day

7.0 (2.5)

7.0 (2.5)

7.6 (2.5)

7.4 (2.6)

6.1 (2.5)

7.8 (2.7)

 NSAIDs, n (%)

156 (79.2)

323 (81.8)

167 (69.9)

173 (71.8)

90 (87.4)

94 (89.5)

  1. AS ankylosing spondylitis, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BMI body mass index, CRP C-reactive protein, IV intravenous, NSAID non-steroidal anti-inflammatory drug, PsA psoriatic arthritis, RA rheumatoid arthritis, SD standard deviation
  2. *Data presented as mean (SD) unless otherwise noted
  3. **Among patients with investigator-assessed spondylitis in addition to peripheral arthritis as their primary presentation of PsA
  4. ***Prednisone or equivalent