Table 2 Biomarker concentrations for the study groups in both cohorts
Aarhus cohort | Groningen GPS cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|
HC | GCA | Isolated PMR | GCA look-alike | HC | GCA | Isolated PMR | Infection control | ||
CRP, median (IQR) | mg/L | 1.1 (0.5–2.9) | 74 (44–102) | 35 (23–73) | 54 (13–107) | 0.7a (0.5–2.4) | 52 (19–97) | 35 (12–67) | 70 (35–107) |
ESR, median (IQR) | mm/h | 8 (4–14) | 73 (63–91) | 53 (33–70) | 75 (32–95) | 9 (5–14) | 88 (50–104) | 55 (36–72) | 60b (18–109) |
Leukocytes, median (IQR) | 109/L | 5.3 (4.6–6) | 9.1 (7.6–10.3) | 9.5 (8.7–10.8) | 8.4 (7.5–9.9) | 6.1 (5.2–7.3) | 9.1 (7.2–11.3) | 8.7 (7.2–10.2) | NA |
Platelets, median (IQR) | 109/L | 235 (214–263) | 423 (353–493) | 401 (329–472) | 337 (275–433) | 240 (214–276) | 364 (301–472) | 321 (278–383) | 275 (199–315) |
VEGF, median (IQR) | pg/mL | 90 (10–183) | 145 (53–334) | 160 (58–318) | 237 (149–326) | 75 (52–143) | 125 (71–269) | 190 (124–239) | 162 (66–280) |
Angpt-1, median (IQR) | ng/mL | 67 (55–81) | 55 (33–68) | 65 (50–93) | 67 (43–96) | 48 (41–60) | 54 (47–67) | 48 (39–66) | 64 (47–81) |
Angpt-2, median (IQR) | pg/mL | 1060 (960–1765) | 2892 (2059–4101) | 2557 (2253–4094) | 2145 (1758–3748) | 952 (616–1570) | 3877 (2158–5610) | 1848 (1552–3028) | 4417 (1878–7832) |
sTie2, median (IQR) | ng/mL | 14 (12–16) | 16 (13–21) | 18 (13–24) | 17 (13–20) | 10 (7–12) | 14 (9–18) | 12 (9–14) | 13 (12–18) |
YKL-40, median (IQR) | ng/mL | 53 (34–75) | 74 (44–125) | 76 (55–131) | 63 (35–140) | 52 (38–80) | 101 (59–148) | 128 (75–165) | 106 (36–162) |
MMP-3, median (IQR) | ng/mL | 14 (11–21) | 15 (10–22) | 38 (28–54) | 22 (13–29) | 11 (8–16) | 10c (8–16) | 24c(16–49) | 27c (18–39) |
MMP-9, median (IQR) | ng/mL | 234 (172–415) | 238 (114–341) | 320 (197–339) | 317 (222–802) | 239 (173–303) | 391c(239–557) | 245c (198–377) | 130c (73–253) |
sCD206, median (IQR) | ng/mL | 105 (92–145) | 210 (171–267) | 173 (137–237) | 255 (191–383) | 125 (107–143) | 180 (139–236) | 145 (127–212) | 196 (124–233) |
Calprotectin, median (IQR) | ng/mL | 1395 (942–1802) | 3310 (2537–4212) | 4200 (2675–5203) | 3505 (2801–6980) | 2712 (2039–4168) | 7028 (3691–10052) | 5862 (4858–7692) | 6774 (4606–8456) |
PR3, median (IQR) | ng/mL | 22 (15–28) | 34 (26–45) | 37 (25–43) | 41 (24–53) | 38 (31–54) | 54 (43–74) | 57 (42–71) | 135 (70–214) |
Elastase, median (IQR) | ng/mL | 69 (59–95) | 103 (91–141) | 133 (84–150) | 115 (89–197) | 110 (98–142) | 122 (80–172) | 137 (116–182) | 253 (157–366) |
A1AT, median (IQR) | mg/mL | 1.7 (1.6–2.0) | 3.5 (2.8–4.0) | 3.0 (2.6–3.8) | 3.0 (2.5–3.6) | 1.6 (1.4–1.8) | 3.5 (2.3–4.4) | 2.7 (2.3–3.7) | 3.8 (2.5–4.9) |