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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Validation in the ESPOIR cohort of vitamin K-dependent protein S (PROS) as a potential biomarker capable of predicting response to the methotrexate/etanercept combination

Fig. 4

Determination of concentration threshold for PROS, CO7 and PROS + CO7 combination using receiver operating characteristic (ROC) from data of both cohorts prior to treatment with etanercept and methotrexate. a Serum PROS (left) or CO7 (right) concentrations in responders (n=33) and non-responders (n=15) prior to etanercept/methotrexate initiation in RA patients who have failed to methotrexate in the 2 cohorts. b ROC curve averaging of PROS (left), CO7 (middle) and PROS+ CO7 (right) prior to MTX/ETA treatment; gray line corresponds to 95% confidence interval. c Table showing the performances of PROS, CO7, and PROS + CO7 combination resulting from ROC curve analysis for prediction of response to MTX/ETA treatment

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Arthritis Research & Therapy

ISSN: 1478-6362

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