Fig. 4

Subgroup analyses based on 24-h urine protein levels with the cut-off value of 3.0g/24h. a–d In the subgroup of patients with 24h UP>3.0 g/24h, a uG3BP levels were significantly increased in proliferative (class III/IV ± V, n=35) LN patients when compared to membranous LN (class V, n=9) (p=0.04) by Mann–Whitney U analysis. b ROC curve analysis for uG3BP to differentiate proliferative and membranous LN with AUC of 0.72 (p=0.04). uG3BP levels positively correlated with c AI score of LN renal histology (ρ=0.389, p<0.01), and d scores of hyaline deposits (ρ=0.418, p<0.01); e–h in the subgroup of patients with 24h UP≤3.0 g/24h, e there was no difference between patients with proliferative and membranous LN in uG3BP levels (p=0.613) by Mann–Whitney U analysis. f ROC curve analysis for uG3BP to differentiate proliferative and membranous LN with AUC of 0.551 (p=0.60). g uG3BP levels showed no correlation with AI score (ρ=0.079, p=0.627). h uG3BP levels correlated positively with scores of cellular/fibrocellular crescents (ρ=0.328, p<0.01). ρ, Spearman’s correlation coefficient. **p<0.01