Table 5 Venous thromboembolism (pulmonary embolism or deep vein thrombosis) risk within 1 year among patients initiating tramadol compared with other propensity score-matched analgesics among patients with OA

 Event (n)

58

44

84

51

79

56

38

30

 Mean follow-up (years)

0.98

0.99

0.98

0.99

0.98

0.99

0.98

0.98

 Rate, per 1000 PY

4.8

3.7

5.4

3.3

5.2

3.7

5.7

4.5

 RD (95% CI), per 1000 PY

1.2 (−0.4−2.9)

1.0 (ref)

2.2 (0.7−3.7)

1.0 (ref)

1.4 (−0.1−2.9)

1.0 (ref)

1.2 (−1.2−3.7)

1.0 (ref)

 HR (95% CI)

1.3 (1.0−1.7)

1.0 (ref)

1.7 (1.3−2.2)

1.0 (ref)

1.4 (1.1−1.8)

1.0 (ref)

1.3 (0.9−1.8)

1.0 (ref)

 Event (n)

30

27

37

31

33

24

17

15

 Mean follow-up (years)

0.98

0.99

0.98

0.99

0.99

0.99

0.98

0.98

 Rate, per 1000 PY

2.5

2.2

2.4

2.0

2.2

1.6

2.6

2.3

 RD (95% CI), per 1000 PY

0.3 (−0.9−1.5)

1.0 (ref)

0.4 (−0.7−1.5)

1.0 (ref)

0.6 (−0.3−1.6)

1.0 (ref)

0.3 (−1.4−2.0)

1.0 (ref)

 HR (95% CI)

1.1 (0.8−1.6)

1.0 (ref)

1.2 (0.9−1.7)

1.0 (ref)

1.4 (0.9−2.0)

1.0 (ref)

1.1 (0.7−1.9)

1.0 (ref)

 Event (n)

33

27

54

27

53

35

24

17

 Mean follow-up (years)

0.98

0.99

0.98

0.99

0.98

0.99

0.98

0.98

 Rate, per 1000 PY

2.7

2.2

3.5

1.8

3.5

2.3

3.6

2.6

 RD (95% CI), per 1000 PY

0.5 (−0.7−1.8)

1.0 (ref)

1.5 (0.3−2.7)

1.0 (ref)

1.2 (0.0−2.4)

1.0 (ref)

1.1 (−0.8−3.0)

1.0 (ref)

 HR (95% CI)

1.2 (0.9−1.8)

1.0 (ref)

2.0 (1.4−2.8)

1.0 (ref)

1.5 (1.1−2.0)

1.0 (ref)

1.4 (0.9−2.2)

1.0 (ref)