| Muscle inflammation | Muscle damage | ||||
---|---|---|---|---|---|---|
 | Mean T2-mapping time | Fat fraction | SMT | |||
Visual imaging assessment | Coefficient (95% CI) | p value | Coefficient (95% CI) | p value | Coefficient (95% CI) | p value |
Muscle oedemaa | 2.46 (0.44–4.48) | 0.019 | − 2.16 (− 5.17 to 0.85) | 0.153 | − 67.99 (− 286.11 to 150.13) | 0.529 |
Fatty infiltration | 3.41 (0.69–6.13) | 0.016 | − 3.28 (− 7.31 to 0.75) | 0.107 | − 128.46 (− 421.60 to 164.67) | 0.378 |
Any chronic muscle damage on MRIb | 3.03 (0.48–5.59) | 0.022 | − 2.32 (− 6.14 to 1.50) | 0.224 | − 149.02 (− 419.69 to 121.64) | 0.279 |
Clinical variable | ||||||
 Age | 0.25 (− 0.12 to 0.17) | 0.728 | − 0.07 (− 0.27 to 0.13) | 0.482 | − 4.28 (− 18.39 to 9.84) | 0.541 |
 mRSS | 0.05 (− 0.05 to 0.15) | 0.315 | − 0.02 (− 0.17 to 0.12) | 0.754 | − 2.61 (− 12.77 to 7.56) | 0.605 |
 mRSS > 14 | 1.73 (− 0.42 to 3.89) | 0.111 | − 1.34 (− 4.46 to 1.78) | 0.387 | − 39.96 (− 262.22 to 182.31) | 0.716 |
 Disease duration | 0.05 (− 0.11 to 0.20) | 0.546 | 0.01 (− 0.20 to 0.22) | 0.934 | − 12.72 (− 27.33 to 1.90) | 0.086 |
 Current prednisolone use | 0.41 (− 1.94 to 2.75) | 0.727 | − 2.36 (− 5.54 to 0.82) | 0.140 | 46.67 (− 185.34 to 278.69) | 0.684 |
 MMT < 5 | − 5.58 (− 8.14 to 3.02) | < 0.001 | 1.44 (− 3.15 to 6.04) | 0.526 | 382.12 (88.80 to 675.44) | 0.012 |
 CK | 0.003 (− 0.007 to 0.01) | 0.602 | − 0.02 (− 0.03 to − 0.01) | 0.006 | 0.94 (− 0.03 to 1.91) | 0.057 |
 ESR | − 0.06 (− 0.14 to 0.01) | 0.079 | 0.002 (− 0.11 to 0.11) | 0.970 | 2.42 (− 5.10 to 9.94) | 0.516 |
 CRP | 0.02 (− 0.21 to 0.24) | 0.879 | 0.12 (− 0.18 to 0.41) | 0.414 | 0.39 (− 21.65 to 22.43) | 0.971 |
 Arthritis | − 2.00 (− 4.09 to 0.09) | 0.060 | 1.12 (− 1.97 to 4.20) | 0.465 | 87.97 (− 129.15 to 305.09) | 0.415 |
 Digital ulcers | − 0.60 (− 2.77 to 1.57) | 0.576 | − 0.29 (− 3.35 to 2.78) | 0.850 | 9.21 (− 206.88 to 225.29) | 0.931 |
 ILD | − 0.94 (− 3.93 to 2.04) | 0.523 | − 1.68 (− 5.84 to 2.49) | 0.417 | 198.43 (− 89.22 to 486.09) | 0.169 |
 FVC < 70% | − 1.94 (− 0.76 to 4.64) | 0.152 | 2.14 (− 1.70 to 5.98) | 0.264 | 230.71 (− 31.87 to 493.28) | 0.083 |
Cardiac imaging | ||||||
 LVEF (CMR) | − 0.05 (− 0.22 to 0.13) | 0.606 | 0.18 (− 0.06 to 0.43) | 0.131 | − 8.41 (− 25.84 to 9.02) | 0.332 |
 LV GLS (CMR) | 0.15 (− 0.35 to 0.65) | 0.545 | − 0.60 (− 1.30 to 0.09) | 0.085 | 18.44 (− 31.38 to 68.27) | 0.455 |
 T1-mapping (SASHA) | 0.04 (0.02 to 0.06) | 0.001 | 0.005 (− 0.03 to 0.04) | 0.780 | − 1.78 (− 4.13 to 0.56) | 0.131 |
 T1-mapping (ShMOLLI) | 0.02 (− 0.01 to 0.05) | 0.117 | 0.02 (− 0.02 to 0.06) | 0.261 | − 0.72 (− 3.63 to 2.18) | 0.614 |
 T2-mapping (FLASH) | 0.23 (− 0.06 to 0.52) | 0.118 | 0.11 (− 0.32 to 0.54) | 0.603 | − 28.41 (− 56.57 to − 0.25) | 0.048 |