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Table 2 Clinical characteristics of study participants (pSTAT5)

From: Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome

 

Healthy

Non-severe

Severe

p-value

n

15

15

16

-

Age (years)

50.3±9.0

59.7±17.2

61.9±17.0

0.66

Sex (% female)

100%

100%

100%

NA

Duration from onset (years)

-

5.7±10.2a

14.8±10.9a

0.064

Duration from diagnosis (years)

-

5.7±7.0

9.8±7.2b

0.079

BMI

-

25.6±4.6b

25.3±6.2b

0.88

Stimulated salivary flow rate

-

7.2±3.1 ml/5 min

1.5±0.9 ml/5 min

6.66 × 10-9

Schirmer right (mm/5 min)

-

8.0±9.3

5.5±5.9b

0.69

Schirmer left (mm/5 min)

-

7.9±7.4

6.5±7.0b

0.61

Anti-SSA

-

11/73.3%

13/86.7%c

0.39

Anti-SSB

-

2/13.3%

5/33.3%c

0.21

Seropositive (SSA and/or SSB)

-

11/73.3%

13/86.7%c

0.39

cMARD

-

5/35.7%d

4/33.3%e

0.93

bMARD (anti-TNF)

-

0/0.0%f

0/0.0%a

NA

Glucocorticoid

-

3/21.4%d

1/9.1%g

0.44

Cyclosporine eye drops

-

3/37.5%h

3/33.3%f

0.91

Oral pilocarpine

-

1/14.3%i

1/12.5%h

1

Natural tears

-

4/40.0%j

2/28.6%i

0.68

Angina pectoris

-

1b

0e

0.38

Autoimmune thyroid disease

-

0

2

0.18

Gynaecologic manifestation

-

1b

0e

0.38

Anemia

-

2b

0e

0.18

Leukopenia

-

1b

1e

1

Neutropenia

-

1b

0e

0.38

Cancer

-

1b

1e

1

  1. Values for continuous variables are presented in mean ± SD. Mann-Whitney U test was used in the comparison between non-severe and severe patients
  2. an=6, bn=13, cn=15, dn=14, en=12, fn=9, gn=11, hn=8, in=7, jn=10