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Table 3 Characteristics of patients with at least one flare during 3-month periods and during year 2

From: One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study

 

Year 1

Year 2

 

0–3 months

3–6 months

6–9 months

9–12 months

 

N with flare

59/189

90/187

52/167

70/186

45/173

Age (years)

56.0 (13.9)

56.9 (13.0)

59.5 (14.7)

57.6 (13.2)

57.1 (12.9)

Disease duration (years)

8.4 (8.6)

8.4 (7.3)

10.2 (9.8) *

9.6 (9.3)

8.8 (6.3)

Baseline > 1 tophus

16.9%

14.4%

19.2%

24.3% *

22.2%

Co-morbidities (SCQ) sum

4.6 (3.9) *

4.0 (3.4)

4.5 (3.4)

4.5 (3.4)*

3.8 (3.4)

Baseline SUA

502 (76)

504 (76)

498 (81)

510 (38)

504 (81)

3 months SUA

361 (76) *

343 (62)

339 (61)

345 (60)

351 (68)

6 months SUA

325 (65)

328 (61)

335 (63)*

331 (63)

331 (66)

9 months SUA

312 (54)

317 (61)

318 (69)

328 (60)

311 (58)

12 months SUA

304 (47)

309 (46)

299 (47)

308 (48)

313 (51)

24 months SUA

330 (80)

331 (79)

323 (68)

337 (85)

328 (67)

Baseline allopurinol user (%)

15.3%

17.8%

13.5%

14.3%

6.7%

Month 3 allopurinol (mg)

238 (86)

239 (98)

224 (105)

253 (97)*

228 (105)

Month 6 allopurinol (mg)

287 (98)

275 (120)

272 (134)

308 (124)**

275 (124)

Month 9 allopurinol (mg)

292 (128)

281 (133)

293 (145)

307 (137)*

291 (146)

Month 12 allopurinol (mg)

303 (126)

295 (135)

301 (146)

333 (142)**

292 (138)

Ever use

 - NSAID

87.5%

79.3%

80.4%

88.1%*

86.0%

 - Colchicine

52.7%

60.0%

57.7%

67.7%*

56.1%

 - Prednisolone

51.8%

53.6%

56.9%

53.1%

52.4%

≥ 1 flare last 12 months

82.5%

82.4%

88.5%

77.6%

90.5%

> 5 previous flares

59.6%

56.8%

63.5%*

59.7%

52.4%*

Strongest pain ever

8.7 (1.3)*

8.5 (1.5)

8.6 (1.2)

8.7 (1.4)

8.7 (1.1)

Strongest pain last flare

7.1 (2.0)

7.2 (2.0)

7.4 (2.0)

7.1 (2.1)

7.3 (1.9)

  1. *p-value < 0.01 and with higher value compared to non-flare group
  2. **p-value < 0.01 and with higher value compared to non-flare group
  3. SUA serum urate, NSAID non-steroidal anti-inflammatory drug