Fig. 5
From: The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling
The effect of oral LG283 on the expression of transcription factors associated with EMT in bleomycin-injected mouse skin. a mRNA expression of indicated transcription factors in skin samples of placebo- and LG283-treated mice on day 7 after bleomycin injection were quantitatively analyzed by real-time RT-PCR. Values represent mean ± SEM; n = 5 each group; **p< 0.01. b Skin sections of placebo-and LG-283-treated mice on day 7 after bleomycin injection were immunostained for SNAIL1 and 2. Scale bar, 50 μm. Representative immunohistochemistry images are shown and staining-positive areas were compared among each group. Values represent mean ± SEM; n = 3 each group; **p< 0.01