Skip to main content
Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats

Fig. 5

Effect of local cryotherapy on endothelial dysfunction in AIA rats. Experiments were conducted in AIA rats treated or not with local cryotherapy. Expression of endothelial pathways involved in AIA-associated endothelial dysfunction including COX-2 (A), Arg-2 (B), p22phox (C), and p47phox (D) was studied in aorta by qRT-PCR. Results are expressed as means ± SEM (n=number of rats/group). E, F Endothelial function was studied in rat on aortic rings and on mesenteric arteries by the measurement of acetylcholine (Ach)-induced vasorelaxation in endothelium-intact artery segments preconstricted with phenylephrine 10−6 moles/L. Results are expressed as means ± SEM (n=number of arterial rings, 6–7 rats/group). *(p<0.05), **(p<0.01), ***(p<0.001)

Back to article page